Abstract
#Interleukin 37 (IL-37) was known as IL-1F7 before Nold
and his colleagues renamed it. Nold believed that IL-37 which
expressed on cells including macrophages or epithelial cells plays
an anti-#inflammatoryeffect under the condition of intracellular and
extracellular. IL-37 almost completely suppresses the production
of pro-inflammatory cytokines, whereas the abundance of these
cytokines increased with silencing of endogenous IL-37 in human
cells [1]. Most studies have now focused on the function of IL-37
as an anti-inflammatory cytokine, while other related functions
are still being explored. An autoimmune disease is a condition in
which the immune system attacks the body [2,3]. Recent research
confirmed that IL-37 is associated with many autoimmune diseases
such as systemic lupus erythematosus (SLE), rheumatoid arthritis
(RA), inflammatory bowel disease (IBD), and multiple sclerosis
(MS) [4-7]. These studies have shown that IL-37 could inhibit proinflammatorycytokines such as TNF-α, IL-1α, IL-1β, IL-6, G-CSF and
GM-CSF [1-3].
For more Biomedical Open Access Journals please click on https://biomedres.us/
For more Research and Review Articles on BJSTR
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.