Dual Role of Interleukin-37 As an #Anti-Inflammatory and A Regulatory #Cytokine In EAE by Zhangbo Chen in BJSTR

Abstract

#Interleukin 37 (IL-37) was known as IL-1F7 before Nold and his colleagues renamed it. Nold believed that IL-37 which expressed on cells including macrophages or epithelial cells plays an anti-#inflammatoryeffect under the condition of intracellular and extracellular. IL-37 almost completely suppresses the production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human cells [1]. Most studies have now focused on the function of IL-37 as an anti-inflammatory cytokine, while other related functions are still being explored. An autoimmune disease is a condition in which the immune system attacks the body [2,3]. Recent research confirmed that IL-37 is associated with many autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS) [4-7]. These studies have shown that IL-37 could inhibit proinflammatorycytokines such as TNF-α, IL-1α, IL-1β, IL-6, G-CSF and GM-CSF [1-3].

For more Biomedical Open Access Journals please click on https://biomedres.us/

For more Research and Review Articles on BJSTR

https://biomedres.us/abstracts/BJSTR.MS.ID.000997.php

https://biomedres.us/fulltexts/BJSTR.MS.ID.000997.php

Dual Role of Interleukin-37 As an #Anti-Inflammatory and A Regulatory #Cytokine In EAE by Zhangbo Chen in BJSTR