Mechanical, Molecular #Myofibrillar and Proteomic Modifications in Muscle Aging: A Pilot Study by Stefano Scarpa in BJSTR

Abstract

Introduction: #Skeletalmuscle tissue is a complex and very important organ for movement, #metabolism and #thermoregulation, but its relevance to health is not always taken in consideration. The muscle is made by a set of syncital fusiform cells called #myocytes, which contein #sarcomeres, the real protein contractile apparatus, composed of myofibrillar cytoskeleton proteins. Muscle tissue undergoes significant remodeling with aging and it changes its contractile phenotype. Aging significantly influences the proteomic structure of the cell as well as the nervous component. We assist to a #physiopathologicalframework where the slowing of #proteinsynthesis is accompanied by an #axonalatrophy essential for efficient muscle contraction. The result of those factors leads to a loss of volume of the muscle fibers, a lower strength and performance.

For more Biomedical open access journals please click on https://biomedres.us/

For more Biomedical Open Access Articles on BJSTR

https://biomedres.us/abstracts/BJSTR.MS.ID.000930.php

https://biomedres.us/fulltexts/BJSTR.MS.ID.000930.php

Mechanical, Molecular #Myofibrillar and Proteomic Modifications in Muscle Aging: A Pilot Study by Stefano Scarpa in BJSTR