Optimization of Biodegradable Nerve Conduit Diameter for #NerveRegeneration by Noritaka Isogai in BJSTR

Abstract

In the treatment of peripheral neurological deficits, #autologousnerve grafting is the first choice. The sural nerve, ante #brachialcutaneousnerve, terminal branch of posterior interosseous nerve, and other choices are commonly used, however, loss of function and potential morbidity from creation of these donor sites are undesirable effects of their use. In recent years, synthetic nerve conduits and #allogeneicnerve grafting materials have been introduced into clinical practice as alternatives to autologous nerve grafting [1-3]. The first attempt at nerve conduit was application for nerve regeneration using silicone tubes [4] Subsequent studies explored biodegradable materials with open internal structure as the conduit. More recently, filling the conduit with a regeneration conducive material such as collagen demonstrated improved nerve regeneration, however, the outcome remained inferior to autologous nerve grafting and allergenic nerve transplantation [5-7]. To promote #nerve #regeneration, biodegradable nerve conduits need to be carefully sutured to the donor nerves at the anastomotic site as the poor adaptation often allows fibroblasts invasion into the lumen of the conduit which hampers nerve regeneration.

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Optimization of Biodegradable Nerve Conduit Diameter for #NerveRegeneration by Noritaka Isogai in BJSTR