Abstract
The thermal behavior of some #anti-inflammatorydrugs: diflunisal,
#tenoxicam and #celecoxib are studied extensively by thermo gravimetric
and differential thermal analyses (TGA/DTA) techniques. The #thermogravimetric data allowed determination of the kinetic and #thermodynamic parameters: activation energy (Ea), frequency factor (Z) activation
entropy (AS#) and reaction order (n) which calculated from TG-curves at
different heating rates using different kinetic models: The relative
thermal stabilities of the anti-inflammatory drugs have been evaluated
on the
basis of the kinetic and thermodynamic parameters. Also, the purities of
these drugs are determined by differential scanning #calorimetric (DSC)
technique and compared with specialized pharmacopoeia methods. Analysis
of the DSC data indicated that the degrees of purity of diflunisal,
tenoxicam and celecoxib were similar to those found by pharmacopoeia
methods (BP and USP). The simplicity, speed and low operational costs
of thermal analysis justify its application in quality control of
#pharmaceuticaldrugs.
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