Two Alternative Approaches to Generate Live Attenuated Influenza Vaccine Candidates against Potentially #PandemicAvianInfluenza H7N9 Virus by Irina Kiseleva in BJSTR

Abstract

Avian #influenza remains a major #pandemicthreat. In response to this threat, the objective of our work was the development of live attenuated reassortant influenza vaccine (LAIV) against recent isolates of potentially pandemic H7N9 influenza viruses which may cause serious and fatal disease in humans. Two H7N9 LAIV candidates were generated by using two different approaches: classical #reassortment in eggs and reverse genetics. The collected data indicate that regardless of the approach both H7N9 LAIV candidates acquired attenuated properties - temperature sensitivity and #cold-adaptation.

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Two Alternative Approaches to Generate Live Attenuated Influenza Vaccine Candidates against Potentially #PandemicAvianInfluenza H7N9 Virus by Irina Kiseleva in BJSTR