Sunday, April 28, 2019

Journal on Medical Genetics

Abstract

The liver is an important organ that supports vital functions, including absorption of #metabolites from #the intestines, regulation of glucose and lipid metabolism, #biotransformation of #xenobiotics,secretion of hormones and maintenance of osmotic balance, etc. Impairment of hepatic functions for any reason maylead to hepatic failure if not treated appropriately [1,2]. Involving many complex events at both cellular andmolecular level, regeneration of the liver is usually divided into three phases [3].The “early phase” is whenthe regeneration starts with a rapid proliferation of the liver cells. It represents #hepatocytestransition fromG0 phase to G1, where the number of newly expressed genes and level of genetic expression is greatlyelevated. The “transition phase” represents the occurrence of mitosis where the cells pass through G1-SG2-M phases during the cell cycle [4].

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