Abstract
Objective: This #in vitro study aims to compare the inhibitory effect of those α-blocker to the #phenylephrine inducedprostate smooth muscle contraction.
Research Method: Twenty eight eligible BPH patients were
randomly allocated to 4 groups which are one control group (without
α-blocker therapy) and 3 intervention groups treated with #silodosin,
#tamsulosin and #terazosine for 7 days prior to TURP surgery. The prostate
tissue samples were taken during TURP surgery. This sample prepared on
organ bath containing #thyrod liquid and further induced with
phenilephrin at dose 10-4μg/ml to measure its contraction. A oneway
anova analysis was performed to investigate the significant difference
among groups.
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