Abstract
Design and application of a #vaccine for #syphilis is proposed. Syphilis, once a widespread and crippling disease, has decreased in prevalence and significance due to public health education and the use of #penicillin, which is extremely effective in curing the disease. This decline has reduced the urgency for a vaccine for syphilis. However, in recent years the incidence of syphilis has been increasing. A persistent reservoir remains in highly impacted groups such as sex workers and men who have sex with men. It is proposed that the critical application of a vaccine for syphilis to these groups could eventually eliminate this disease. Evidence is presented that the most effective immune response to syphilis infection is delayed type #hypersensitivity (DTH). In this review a design for a vaccine for syphilis directed to the induction of DTH is described.
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A Vaccine for #Syphilis by Stewart Sell in BJSTR
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