Journals on Medical Informatics - BJSTR Journal

Abstract

For #collagen obtained from young fish air bubbles, using the gravitation #massspectroscopy method (GMS) the dynamics of the long-range order (LRO) change in the whole domain ensemble up to 3 billion Da was studied. LRO was represented by the masses of the simplest domains (loops, spirals), sub micelle and micelle structures, seed fibrillary crystals and giant aggregates (2...3 billion Da). The process of the LRO varying occurred under the influence of the gravitational noise (GN) from the universe. The form of the mass distribution in LRO depended on the age of the fish.The ageing of collagen as well as of other molecular systems occurs not only at the level of chemical processes, but also at the little-known level of LRO. On the other side it is known that LRO in molecular systems is formed under the influence of #gravitational noises of the universe which can be represented as the effect of sound waves on disperse systems. Here these heterogeneous structures were forced to form new structures with minimal potential energies. It was of interest to trace the dynamics of such events in the collagen LRO. The purpose of this work was to analyze LRO in collagen and the causes of its ageing as well as. Fresh and aged fish air bubble collagen (Figure 1) served as investigation objects. The GMS spectra were taken using the procedure described in [1] by means of weak shock waves. The spectra were then calculated with the help of the Zubow force constant Z = 6.55E-15 N/m. Prior to the measurement the samples were dried at 320 ± 5 K. The positive signals in the spectra were ascribed to the energy part of the expanded domains in the whole mass ensemble (f), the negative (-f) - to that one of the collapsed domains. Remember once more that the GMS signals depend less on the concentration of the coils/domains, than on their mass (clusters of atom nuclei) dynamics (changes in conformations, configurations of individual chain fragments, movement of coils, and their forced deformation). Based on these properties the method made it possible to isolate the signals from the active mass clusters and to identify them.

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Influence of #GravitationalNoises on the Long-Range Order in Collagen by Kristina Zubow in BJSTR