Abstract
SiO2 films are deposited on microscopic glasses by dip- or
spin coating using sol-gel produced starting solution. The morphology
of the films is characterized by means of atomic force microscopy (AFM).
The IR #spectroscopy proved the presence of Si-OH groups on the surface
of the films. The films as substrates for red blood cells in the present
of fluoro-4 are studied by fluorescent microscopy. The shape change of
the red blood cells can be connected with the IEP of the SiO2 and the influence of the hydrophilic surface of the thin glass film. Under non-pathological conditions the human red blood cells (RBCs) can
occur in different resting shapes - #stomatocytes with "moon like" shape,
#discocytes with biconcave-disk shape, and #echynocytes with protrusions
or spicules. The normal discocyte is able to transform to either
stomatocytes or echinocytes by changing the environmental conditions.
Among different agents causing the modification of the discocytes to
echynocytes both the proximity to a glass surface and high pH can be
pointed out [1-3].
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Sol-Gel Produced Sio2 - Films for Observation of Red Blood Cells by Maria Milanova in BJSTR
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