Abstract
The atherosclerosis is a complex #pathological process that influences
lipid deposition in the intima of middle- and large-sized arteries.
AMP- activated protein kinase (AMPK) is a nutrient sensor that
stimulates ATP production and fatty acid oxidation, but inhibits
#lipogenesis. Moreover, AMPK plays a key role in regulating oxidative
stress, inflammation and vascular smooth muscle cells de-differentiation
involved in #atherosclerosis progression. Atherosclerosis is considered as one of causes of morbidity and
premature disability in developed countries. Atherosclerosis is a
complex chronic pathological disorder that affects many organs in human
body causing #ischemia of brain, extremities or heart leading to
infarction depending on vessel involved [1]. It is characterized by the
#subendothelial accumulation of #fibrofatty deposits in the intima of
large arteries. Atherosclerosis was formerly regarded as a bland lipid
storage disease, but recent studies have illustrated the role of
inflammation, oxidative stress, immune system and #endothelium on
progression of atherosclerotic lesions [2]. Major risk factors for
atherosclerosis involve #hypercholesterolemia, dyslipidemia,
hypertension, diabetes, inflammation, smoking, obesity, old age and
family history of heart diseases [3].
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The Functional Link between AMPK Pathway Activation and Atherosclerosis Progression by Kholoud Alaa El Mihi in BJSTR
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