Journals on Medical Microbiology - BJSTR Journal

Abstract

The atherosclerosis is a complex #pathological process that influences lipid deposition in the intima of middle- and large-sized arteries. AMP- activated protein kinase (AMPK) is a nutrient sensor that stimulates ATP production and fatty acid oxidation, but inhibits #lipogenesis. Moreover, AMPK plays a key role in regulating oxidative stress, inflammation and vascular smooth muscle cells de-differentiation involved in #atherosclerosis progression. Atherosclerosis is considered as one of causes of morbidity and premature disability in developed countries. Atherosclerosis is a complex chronic pathological disorder that affects many organs in human body causing #ischemia of brain, extremities or heart leading to infarction depending on vessel involved [1]. It is characterized by the #subendothelial accumulation of #fibrofatty deposits in the intima of large arteries. Atherosclerosis was formerly regarded as a bland lipid storage disease, but recent studies have illustrated the role of inflammation, oxidative stress, immune system and #endothelium on progression of atherosclerotic lesions [2]. Major risk factors for atherosclerosis involve #hypercholesterolemia, dyslipidemia, hypertension, diabetes, inflammation, smoking, obesity, old age and family history of heart diseases [3].

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The Functional Link between AMPK Pathway Activation and Atherosclerosis Progression by Kholoud Alaa El Mihi in BJSTR