Abstract
Chronic psychological stress is a main #etiological factor for
autoimmune disease by releasing neuropeptides activates inflammatory
mediators such as IL-iβ, TNF-α, IL-6, and COX-2. These inflammatory
mediators induce NF-KB transcription factor involved in chronic
inflammation, immune modulation, cellular changes, and tissue damage,
augments an autoimmunity. Beta-endorphins is an abundant #endorphin,
natural #neuropeptides synthesized and stored in the anterior pituitary
gland through hypothalamus mediated by autonomic nervous system (ANS),
in response to stressful conditions such as physical exercise, yoga, and
meditation. Beta- endorphins involved in treatment of autoimmune
diseases by reduction of stress and inflammation. This article
highlights about the role of #beta-endorphins on auto-immune diseases.Endorphins are endogenous #morphine, #neuropeptides produced from
pituitary gland in response to stress and pain. There are three types of
endorphins p- endorphins, #enkephalins, and dynorphins binds to mu,
kappa, and delta receptors located on nerves and immune cells.
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