Journals on Medical Research - BJSTR Journal

Abstract

As the largest human #parasitic disease globally, #malaria is a significant public health problem [1-3]. In the world, 40% of the population are at risk of malaria infection. Programs have reduce the incidence of the disease and the associated mortality by 30% and 47% respectively between 2000 and 2013 4. However, although progress has been good, a lot remains to be done; 198 million cases of malaria and 584 000 associated deaths still occur every year [4]. Early and proper treatment of cases is one of the pillars of #malaria control. It has unfortunately come up against the emergence of resistance to the anti-malaria molecules used in #mono-therapies so far. The WHO had therefore recommended #bi-therapies with #artimisinin combination therapies (ACTs) [5,6] and asked countries to ensure a permanent monitoring of their effectiveness [7]. In Africa, most cases and #fatalities occur in non-immunized persons, #pregnant women and children. Every minute, a child dies of malaria. That represents 22% of all child deaths. But, with an increase in funds for malaria control, RDTs and ACTs has grown from 68% in 2005 to 75% in 2011, especially in sub-Saharan Africa. In Senegal, malaria related morbidity has dropped from 33.57% in 2006 to 3.07% in 2009. The National Malaria Control Program (PNLP) adopted ACTs in 2006 as the recommended treatment for uncomplicated malaria with Plasmodium falciparum [8].

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Artemisinin Derivatives Based Therapeutic Combinations for The Treatment of Uncomplicated Plasmodium Falciparum Malaria: Find-Ings of a Meta-Analysis of Surveys Carried Out in Senegal by Papa Ndiaye in BJSTR