Journals on Emergency Medicine - BJSTR Journal

Abstract

Objective To investigate the efficacy and safety of preoperative therapy with imatinib for unresectable/potentially resectable gaster and duodenum gastrointestinal #stromal tumor (GIST). Methods The #clinicopathological data of 16 patients diagnosed with unresectable/potential resectable gaster and duodenum GIST who received #imatinib as preoperative therapy at the Affiliated Hospital of Inner Mongolia Medical University from July 2010 to June 2015 were retrospectively analyzed. Results The median time of preoperative therapy with #imatinib was 7.5months. Image study for response assessment was achieved in all 16 cases, and all of them gained partial response PR after 3-9months #preoperative therapy. Among them, 14 patients received R0 resection and 2 patients gave up surgery due to old age. During the preoperative treatment of imatinib, the incidence of adverse effect of grade 3 or above was 25.0% (4/16) , including 2 cases of #neutropenia, 1 case of rash (grade 3), and 1 case of skin and digestive tract tissue #edema (grade 4). The remaining patients were with grade 1 to 2 adverse effect. The median time of follow-up check was 47 (37-96) months, 3-year disease-free survival rate and overall survival rate are 81.25% and 100% respectively.

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Imatinib Preoperative Treatment for Gastrointestinal Stromal Tumors Clinical Analysis of 16 Cases by Liu Ming in BJSTR