Journals on Medical Microbiology - BJSTR Journal

Abstract

Cancer is a disease extremely difficult to defeat. Besides tumor cells, the #microenvironment is influencing progress and metastasis. Recently, it has been discovered that macrophages may promote progress of the tumors. Those #tumors associated macrophages (TAMs) are still not completely defined and their role not fully described. If the phenotype of the macrophages can influence the outcome of the tumor disease, the focus should be on TAMs and their potential in development of personalized therapy in fighting #metastatic tumors.Steps necessary for the change from normal to malignant cell include numerous alterations in cell #physiology. For example, cancer cells gain mutations and do not respond to external inhibitory signals. Additionally, changes in their DNA allow them to proliferate without need for the external growth factors [1,2]. Moreover, surrounding environment in necessary for the progression of tumors. In 1863, Rudolf Virchow proposed that tumor initiates at the site of chronic #inflammation and that tissue injury with inflammation may increase cell proliferation and cancer progression [3]. In 1986, Dvorak made an expression "tumors are wound that never heals", thus comparing tumor with parasites evoking wound healing response to obtain the surrounding #stroma for their survival and growth [4,5].

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Tumor Associated Macrophages (TAMs) In the World of Cancer by Bihorac Ajna in BJSTR