Journals on Medical Informatics - BJSTR Journal

Abstract

#PABA is a well-known water-soluble vitamin H1 of group B (folic acid). Its high genetic activity as an antimutagen and antioxidant agent has proven in vivo and in vitro. The new scientific data on the mutual PABA + NO application gave rise to some amazing results. Complex PABA/NO is a nitric oxide-releasing agent which selectively activated in cancer cells to over express GSTP1. PABA/NO was efficient in some cancer models in vivo and in vitro. PABA/NO is a promising prodrug in medicine.#Para-aminobenzoic acid (PABA) - Vitamin H1 of group B and a key cofactor for the folic acid production in bacteria [1] has obtained fundamental and practical interest as a unique water- soluble natural #antimutagen since 1979 [2-4]. A priority data obtained by Russian geneticist Josef Rapoport in the 1950-th have revealed the morphogenic effects of PABA in #Drosophila. Then investigations of the different test objects led to the detailed research of the amazing PABA activities. Firstly, in the experiments with the potent chemical mutagens - #alkylating agents, UV- and gamma irradiation S Vasilieva et al. [5]

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 A Recent Genetic and Antioxidant Functions of Vitamin PABA: A Review by Svetlana Vasilieva in BJSTR