Journals on Medical Microbiology - BJSTR Journal

Abstract 

#Alzheimer’s disease (AD), a progressive and debilitating #neurodegenerative disorder, is the most common cause of dementia with a global prevalence at 46.8 million in 2015. An estimated 5.5 million people in the USA are living with AD in 2017, a number expected to grow to 13.8 million in 2050. By then, nearly one million new cases are projected to develop per year, that is to say one new case develops for every 33 seconds [1]. Treating AD is a healthcare and societal priority and the cost of care and the burden on#caregivers keep increasing [2]. However, it is still irremediable yet, and none of the treatments available today prevents or reverses the damage to neurons that causes the disease. Thus, there is an urgent need for more effective therapeutic approaches and researchers are looking for new therapies with breakthroughs. #Danggui ShaoyaoSan (DSS), a classic formula of traditional Chinese medicine (TCM), has become a focus of attention for many researches due to its favorable potency against AD [3,4].This formula was first recorded in the Jing Gui Yao Lue by Zhongjing Zhang (150–219 A.D.) and its #therapeutic effect on AD was first reported by Japan researchers in the 1980s.5 Its protective actions of inhibiting neuronal damage, enhancing cognitive behavior, and improving #mitochondrial impairment have been well documented [6-10]. 

 

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Revealing the Molecular Mechanisms of Danggui Shaoyao San in The Treatment of Alzheimer’s Disease: A Preliminary Study Based on Network Pharmacology  by Rong Qiang Liu in BJSTR