Abstract
Complexes of some #lanthanoids with several #biscoumarin compounds such
as 3,3'- benzylidenebis(4-hydroxy-2H-chromen-2-one),
3,3'-[(2-methoxyphenyl) methylene)]bis(4-hydroxy-2H-chromen-2-one),
3'-[(4-methoxyphenyl)methylene)]bis(4-hydroxy-2H-chromen-2-one) and
3,3'-[(4-chlorophenyl)methylene)]bis(4-hydroxy-2H-chromen-2-one) were
synthesized. The assessment of toxicity both ligands and the complexes
formed was made through testing their antibacterial properties and
cytotoxicity as two independent activities were studied. Three Gram-
positive microorganisms were used, #B. Mycoides, B. Subtilis and S. Lutea,
applying the double layer agar hole diffusion method. The tested
compounds were active against Gram-positive bacteria, but no activity
was measured against Gram-negative bacteria. Cytotoxicity evaluation was
made against cell lines such as K-562, BV-173, and SKW-3. The cluster
analysis as a technique of the statistical data analysis was applied to
the results obtained. Coumarin (2H-1-benzopyran-2-one) and its derivates are large class of
chemical compounds, most of them naturally occurring and can be found in
plants [1], fungi and bacteria [2,3] or can be synthesized with a
modification of the coumarin ring [4-6]. Due to the different types of
substitution of the parent ring, #coumarins are extremely variable in
structure resulting in variety of their properties. Both natural and
synthetic coumarins are reported to have properties such as antioxidant
[7,8], #antifungal [9,10], #antitumor [11-13], anti-HIV [14,15],
anticoagulant [16,17], antibacterial [18-20], etc.
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Assessment of Toxicity Issues of Bis-Coumarine Derivates and their Lanthanoid Complexes by Statistical Data Analysis by M Milanova in BJSTR
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