Abstract
#Alzheimer's disease (AD) is a #neurodegenerative disease characterized by progressive #cognitive impairment. The #neuropathology of
AD is represented by widespread deposits of neurofibrillary tangles
(NFTs) formed by phosphorylated tau (p-tau) protein and of senile
plaques (SP) containing amyloid β (Aβ) protein. A series of
epidemiological statistical results and the experimental study showed
that solely SP cannot result in AD clinical dementia symptoms, while the
formation and the number of NFTs is directly related to the occurrence
of dementia. NTFs formation is due to excessive phosphorylated tau
protein occurred after the formation of the structure of the double
helix shape. Actually, tau, a #microtubule-binding protein, primarily
promotes #microtubule stability and contains 2-3 phosphate groups per
molecule in the normal brain. However, in the AD brain, tau #protein hyperphosphorylated, containing 5-9 phosphate groups per molecule, has a
decreased ability to combine with microtubules and dimerize. Stable tau dimers form tau oligomers, which continue aggregating to form
subunits of filaments called protomers. Two protomers wound around each
other form a #paired helical filament (PHF), and excessive PHF assembly
leads to NFTs and eventually AD [1]. An imbalance between tau
phosphorylation and dephosphorylation is critical to AD tauopathy.
Several protein kinases, including cyclin-dependent kinase 5 (CDK5),
cyclic AMP- dependent protein kinase (PKA) and glycogen synthase kinase
3β (GSK3β) have been confirmed to phosphorylate tau protein at different
sites, such as at serine (Ser) 199, Ser202, Ser262, Ser396, Ser214,
Ser404, Thr231 and other sites of tau protein.
For more articles on BJSTR Journal please click on https://biomedres.us/
For more Scientific and Technical Research Articles on BJSTR
Okadaic Acid Induces the Rats' Memory Impairment and Tau Protein Hyperphosphorylation And Intervened by Flavonoids from Stem and Leaf of Scutellaria Baicalensis Georgi by Shang Yazhen in BJSTR
Follow on Twitter : https://twitter.com/Biomedres01
Follow on Tumbler: https://biomedres.tumblr.com/
Like Our Pins On : https://www.pinterest.com/biomedres/
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.