Abstract
We reported two cases being treated with HRT for the past 7~11 years
presenting no progression in #atherosclerosis. The first case was
diagnosed of having CETP deficiency (homozygosity type) and #fibromyalgia
at the age of 52. The HDL-cholesterol level was around 200 mg/ ml, CETP
DNA point mutation found in intron 14 variant type (A/A) and exon 15
wild type (A/A) were obtained. HRT relieved myalgia and joint pain as
well as JFIQ baseline score 9 1 was reduced to 36, following a 3 months
therapy. The second case was diagnosed as a Tangier disease, presenting
1~2 mg/dL of HDL cholesterol and a very low level of LDL-C at the age of
52. Her ANA with #anti-centromere antibody 80 at the first visit rose to
640. Depression and shortness of breath disappeared while HRT was
continued, However, HRT was discontinued for four years, which made
osteoporosis and Altzheimer's disease more progressive. The patient
remained in good health as a result of the E3 2 mg/day and #atocopherol
600 mg/day that she has been receiving since 2015. In both cases, HRT
served as a good therapy for mid aged women in the prevention of
atherosclerosis.
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Two Long-Term Follow-Up Cases Preventing Atherosclerosis by Hormone Replacement Therapy-CETP Deficiency and Tangier Disease by Kiyomitsu Miyachi in BJSTR
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