Journals on Medical Microbiology - BJSTR Journal

Abstract

For several years, we conducted a study of the role of genetic factors in the pathogenesis of #echinococcosis among residents of the Republic of Bashkortostan. The associations of #polymorphic allele’s genes of cytochrome P-450 (CYP1A1, CYP1A2), glutathione-S-transferases (GSTM, GSTT), cytokines (TNFA), the specificities of Human Leukocyte Antigens (HLA-A, B, DRB1, DQB1) and blood groups AB0 with echinococcosis have been studied. Based on the analysis of the results, it was shown that #genetic factors play a role in the invasion of Echinococcus granulosus with genotype G1 (common, domestic sheep).For several years, we conducted a study of the role of genetic factors in the pathogenesis of echinococcosis among residents of the Republic of #Bashkortostan. They considered that the systems most interested in the development of echinococcosis, which ensure the biological individuality of the organism. These are genes involved in the recognition of “foreign” and the neutralization of foreign toxins (including products of helminth metabolism). Therefore, the genes of the immune response and detoxification of xenobiotics were investigated. The associations of polymorphic allele’s genes of cytochrome P-450 (CYP1A1, CYP1A2), #glutathione-S-transferases (GSTM, GSTT), #cytokines (TNFA), the specificities of Human Leukocyte Antigens (HLA-A, B, DRB1, DQB1) and blood groups AB0 with echinococcosis have been studied. Based on the analysis of the results, it was shown that genetic factors play a role in the invasion of Echinococcus granulosus with genotype G1 (common, domestic sheep). 

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Role of Genetic Factors in the Course of Echinococcosis Disease by Lukmanova GI in BJSTR

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