Abstract
#Multidrug resistant bacteria are marching and winning. The entire
human race is at risk and new, effective antibiotics are needed for
survival. Several notable routines to develop novel antibiotics are
briefly compared here and possible new strategies are proposed. Key
words include but not limited to nanotechnology, metal #nanoparticles,
natural product, medicinal plants, folk medicine, #ethnopharmacology,
computer-based screening, synergistic antibacterial activity, #genomics,
peptides, inhibitor, and structure-based virtual screening.Threat from drug-resistant bacteria increases steadily and globally. As
reported in 2016, over 700,000 people die, and millions suffer from
drug-resistant pathogens each year. It is expected that 10 million
people could be killed a year by 2050, based on the current rate of
antibiotic approvals [1]. There are two main causes for the lack of
effective, new #antibiotics. First, there has been no new antibiotics
developed since 1980s. Most pharmaceutical companies dropped their
program for antibiotic development after the peak of antibiotic
discovery going back to 1940s [2].
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New Antibiotics: Where Are They? by Hua Deng in BJSTR
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