Journals on Medical Casereports - BJSTR Journal

Abstract

It is known that the causative diseases of secondary #hypertrophic pachymeningitis (HP) include infections, malignant tumors, autoimmune diseases. Although myelodysplastic syndromes (MDS) are often accompanied by certain autoimmune diseases, secondary HP with MDS is rare. We here describe the patient with HP complicated by MDS and have severe resistance to the steroid therapy and successfully treated with the combination of #corticosteroids and 5-Azacytidine (5-Aza). Administration of 5-Aza might be a useful therapeutic option for patients with refractory autoimmune diseases complicated with MDS.Hypertrophic pachymeningitis (HP) are secondarily caused by various diseases such as infections, malignant tumors, and autoimmune diseases [1]. Myelodysplastic syndromes (MDS) are #hematopoietic malignancies characterized by pancytopenia in the peripheral blood and is often complicated by autoimmune diseases [2-4]. However, there are few reports of MDS complicated by HP 5-Azacytidine (5-Aza) is the first-line treatment options for high-risk MDS patients, for whom #allogeneic hematopoietic transplantation is not eligible due to the old age and/or comorbidities. Here we report the first case of MDS complicated by HP, which was successfully treated with the combination of 5-Aza and corticosteroids.

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Successful Treatment of Hypertrophic Pachymeningitis Complicated with Myelodysplastic Syndromes with 5-Azacytidine by Chisato Ashida in BJSTR

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