Abstract
Background/Objectives: Given that western diet (WD) intake has
negative impact on development of non-alcoholic fatty liver disease
(NAFLD), the protective effects of Angelica keiskei juice (AK) against
#hyperlipidemia and hepatic steatosis were investigated in WD-fed
C57BL/6J mice.
Materials and Methods: Animals were assigned into four groups
(n=8/group) to receive normal diet + vehicle, WD + vehicle, WD + low AK
(2 g/kg body weight), and WD + high AK (4 g/kg body weight) for 18
weeks. Biochemical analysis was performed for lipid profile in plasma;
histological assessment for steatosis, inflammation, and tissue damage
in the liver and intestine; and qPCR analysis for intestinal #lipoprotein lipase and hepatic endoplasmic reticulum (ER)/oxidative stress markers.
Results: AK significantly attenuated WD-induced increases in
plasma triglyceride and very low density lipoprotein (P=0.001 for both),
and hepatic triglyceride (P<0.001). Particularly, high-dose AK was
effective in #maintaining intestinal barrier integrity and increasing
mRNA expression of hepatic nuclear factor erythroid 2-related factor 2
(P=0.003). It also tended to modify mRNA expressions of intestinal
lipoprotein lipase (P=0.004), and hepatic carnitine palmitoyl
transferase 1a (P=0.038), endoplasmic reticulum nuclei-1 (P=0.014), and
NAD(P)H: quinone oxidoreductase 1 (P=0.047).
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Daily Consumption of Angelica Keiskei Juice Attenuated Hyperlipidaemia and Hepatic Steatosis Caused by Western Diet in C57BL/6J Mice by Oran Kwon in BJSTR
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