Abstract
Background: #Malignantphyllodes #tumours are rare cancers of the breast. #Surgery is the primary mode of treatment and current adjuvant
treatments appear ineffective. Survival is extremely poor when distant #metastasis develops.
Aim: We retrospectively reviewed 30 women who underwent
surgery for malignant phyllodes tumours at our unit over a 16-year
period.
Clinical outcome, particularly the development of distant metastasis,
was examined and factors associated with distant metastasis were
evaluated.
Results:Median age was 55 years. All but 2 women presented
with a palpable breast mass, which was larger than 10cm in 8. In total,
21
women underwent mastectomy and 9 a wide local excision. Margins remained
involved in 4 women even after a #mastectomy and 3 received
post-operative #radiation. Distant metastasis was found in 1 woman on
staging scans done in the immediate post-operative period and in
another 6 women a median of 5.3 months after surgery. None received
#chemotherapy and median survival after the development of distant
metastasis was 2.2 months. Surgical margin involvement was the only
factor associated with distant metastasis (P = 0.031, OR 16.499, 95% CI
0.005 to 0.740), but was not significant after adjusting for tumour size
(P = 0.135, OR 8.348, 95% CI 0.518 to 134.650). Overall survival was
25.5
months and was strongly associated with distant metastasis (P <0.001,
HR495.1, 95%CI 55.84 to 4390).
Management of #Malignant Phyllodes #Tumours of the Breast by Ern Yu Tan in BJSTR
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