Journal on Medical Genetics - BJSTR Journal

Abstract

The mixed systems of bovine serum albumin (BSA) and #surfactants were widely used in biological, foods, pharmaceutical and cosmetics. In this work, trimeric (methyldodecylbis [2-(#dimethyldodecylammonio) ethyl] #ammonium tribromide surfactant (C₁₂-C₂-C₁₂-C₂-C₁₂·3Br-) and Gemini surfactant 1, 2-ethane bis (dimethyldodecylammonium bromide) (C₁₂-C₂-C₁₂·2Br-) were synthesized. And the interaction of trimeric surfactant (C₁₂-C₂-C₁₂-C₂-C₁₂·3Br-), Gemini surfactant (C₁₂-C2-C₁₂·2Br-) and #Monomeric Surfactant (Dodecyl trimethyl ammonium bromide: DTAB) with BSA were explored systematically by surface tension, fluorescence methods dynamic light scattering (DLS). The results suggested that the trimeric surfactants have the greatest effect on BSA unfolding comparing with the corresponding Gemini and monomeric surfactants. Furthermore, C₁₂-C₂-C₁₂·2Br- also have much stronger binding ability with BSA to induce the denaturation of BSA at lower concentration of C12-C2-C12·2Br- Compared with DTAB. Those results will attribute to understand the #physicochemical effect of surfactant architecture on its interaction with #biomacromolecules and broaden their potential applications in medicine.

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The Interaction of Bovine Serum Albumin with Trimeric (Methyldodecylbis [2- (Dimethyldodecylammonio) Ethyl] Ammonium Tribromide and Make A Comparison with Corresponding Gemini and Monomeric Surfactants by Yazhuo Shang in BJSTR