Journals on Biomedical Imaging - BJSTR Journal

Abstract

#Pelvic floor dysfunction is a complex of disorders of the #fascialstructures and pelvic floor muscles that keep the pelvic organs in a normal position and provide continence of urine and feces [1-6]. The POP amounts 30.8% in the structure of urogynecological pathology in European countries [7], in the Middle East countries - 19.9-49.6% [4], in the countries of North and East Africa - 46-56% [8]. In recent years, the incidence of POP has been increasing worldwide [9]. However, despite the growing prevalence of pelvic floor dysfunction in women, there is no consensus on its etiology and #pathogenesis to date. Herewith, there is no doubt that this is a multifactorial pathology, the development of which is determined by genetic and environmental factors. The environmental factors contributing to the development of pelvic floor dysfunction in women have been studied quite well. Those include traumatic and prolonged labor, estrogen deficient conditions, diseases accompanied with increased #intra-abdominal pressure (bronchitis, bronchial asthma, constipation, etc.), disturbance of #microcirculation of blood and lymph in the small pelvis, obesity, and sedentary lifestyle [5,10,11]. As for genetic factors, already at the beginning of the 20th century it was known about existence of family cases of POP. This fact served as the basis for conducting large-scale studies using classical methods of genetic analysis – clinical-genealogical, population-statistical and twin studies, aimed to elucidate the role of hereditary factors in the development of pelvic floor dysfunction in women. The generalized results of these studies have convincingly demonstrated that in families of probands (patients) a pelvic floor dysfunction occurs 3-5 times more often than it would be expected based on the frequency of this pathology in population.

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COL3A1 Gen Polymorphism in Women with Pelvic Floor Dysfunctions: A Case Control Study by Vishnevsky DA in BJSTR