Journals on Medical Drug and Therapeutics - BJSTR Journal

Abstract

Discovery of #biomarkers of #mental disorders for evaluation of efficacy of #psychopharmacotherapy is an important task. The last years it became clear that disturbances in molecular processes in pathological conditions can be connected with #conformational changes in protein structure [1,2]. The aim of the study was to investigate the blood albumin conformation in patients with #melancholic depression (MD) under pharmacotherapy using fluorescent laser spectroscopy. There were investigated 22 patients with melancholic depression (dep) (14 women and 8 men). Patient’s state according to ICD-10 criteria was defined as a depressive episode in the frame of bipolar depressive disorder (type 2) (F32) and in the structure of recurrent depressive disorder (F33). Patients with MD were investigated in dynamics of antidepressant therapy (venlafaxine - 75-150 mg/daily): at admission, on 15th and 30th days of treatment. Control group (con) consisted of 54 volunteers. Investigation was performed in accordance with the permission of the local ethical committee of Moscow Research Institute of Psychiatry (N 16, 13.03.2017). Sub nanosecond laser time resolved fluorescence spectroscopy (SLTRFS) with K-35 fluorescent probe (#dimethylaminonaphthalic acid N-carboxyphenylimide, CAPIDAN) was used for the investigation of #albumin conformation.

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Serum albumin conformation in patients with melancholic depression under antidepressant therapy by Uzbekov M G in BJSTR