Journals on Biomedical Science - BJSTR Journal

Abstract

The problem of the location of #glioblastoma (GB) stem cells (GSCs) and of their relationship with the microenvironment is discussed. Also in our experience, they are located in #perivascular and #perinecrotic niches. In the latter, as an alternative hypothesis to their origin by hypoxia through #Hypoxia Inducible Factor 1, they could represent the remnants of stem cells/progenitors that populate the highly #proliferative areas of GB where necrosis develops in avascular zones due to the imbalance between the high proliferation rate of tumor cells and the low one of endothelial cells. On the whole, tumor stem cells and tumor non-stem cells are in equilibrium between differentiation and stemness, regulated by the #microenvironment with the possibility of an interconversion of the cell statuses.One of the most credited hypotheses on #tumorigenesis is the origin of tumors from cancer stem cells (CSCs). These would be at the top of a cell hierarchy and responsible for growth, recurrence and resistance to therapies. There would be an equilibrium between CSCs and cancer non-stem cells through an interconversion from one to another [1].

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Glioblastoma: Equilibrium and Interconversion Between Tumor Non-Stem Cells and Tumor Stem Cells by Cristina Casalone in BJSTR