Journals on Infectious Diseases - BJSTR Journal

Abstract

Tani et al. [1] earlier described fenestrae in #Golgi apparatus and endoplasmic #reticulum cisternae of human brain tumors. Tougard et al [2] found short discontinuous Golgi cisternae in tumoral prolactin cells in culture. #Petito and #Pulsinelli [3] described transformation of Golgi apparatus into large clusters of small vesicles without cisterns in cortical and striatal neurons following cerebral ischemia. Petito [4] showed transient swelling of Golgi apparatus in #perineuronal oligodendroglial cells in areas of ischemic neuronal necrosis. Blanchette-Mackie [5] found abnormal accumulation of cholesterol at the level of Golgi complex in fibroblasts of patients with Type-C Niemann-Pick disease. Palacios [6] observed beta- amylod precursor protein localization in the Golgi apparatus of normal and axotomized rat neurons. Lucassen et al. [7] reported increasing size of Golgi apparatus in human #supraventricular nucleus neurons in aging and in Alzheimer's disease. Pathological disorders of Golgi apparatus have been also described by Ghadially [8] in a variety of non-nervous diseases involving altered secretory activity (#albuminemia, lipoproteinemias), cell surface pathology (cancer) and viral diseases.

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Ultrastructural Pathology of Golgi Apparatus of Nerve Cells in Human Brain Edema by Orlando J Castejón in BJSTR