Journals on Emergency Medicine - BJSTR Journal

Abstract

Vitamin D Receptor (VDR) #polymorphisms have been investigated in the context of some autoimmune liver diseases, such as primary #biliarycirrhosis (PBC) and autoimmune hepatitis (AIH). However, the association between VDR and #autoimmune live diseases is still controversial and ambiguous. Hence, we integrate previous finding and explore whether this #polymorphism is associated with susceptibility to autoimmune liver diseases. A meta-analysis was performed by Pubmed, Ovid, Medline, and Web of science databases, with the last report up to February 2012. #Casecontrolstudies containing available #genotype frequencies of VDR were chose. The odds ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of association. A total of 6 publications containing 9 studies (7 studies about VDR, 2 studies about AIH) including 844 cases and 1,522 controls were identified. The combined results based on all studies showed that there was a statistically significant link between Apa1 and #autoimmune liver diseases (OR=0.85, 95%CI 0.74-0.96, P=0.058, for a vs. A; OR=0.75, 95%CI 0.58-0.97, P=0.212, for aa vs. AA; OR=0.78, 95%CI 0.63-0.98 P=0.235, for Aa vs. AA; OR=0.77, 95%CI 0.63-0.94, P=0.231, for Aa+aa vs. AA), while the Bsm1 and Taq1 don’t show the association with autoimmune liver diseases.

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Polymorphisms in the Vitamin D Receptor Gene and Risk of Autoimmune Liver Diseases: A Meta-Analysis by Wei Chen in BJSTR