Abstract
Vitamin D Receptor (VDR) #polymorphisms have been investigated in the
context of some autoimmune liver diseases, such as primary #biliarycirrhosis (PBC) and autoimmune hepatitis (AIH). However, the association
between VDR and #autoimmune live diseases is still controversial and
ambiguous. Hence, we integrate previous finding and explore whether this
#polymorphism is associated with susceptibility to autoimmune liver
diseases. A meta-analysis was performed by Pubmed, Ovid, Medline, and
Web of science databases, with the last report up to February 2012.
#Casecontrolstudies containing available #genotype frequencies of VDR were chose. The
odds ratio (OR) and its 95% confidence interval (95%CI) were
used to assess the strength of association. A total of 6 publications
containing 9 studies (7 studies about VDR, 2 studies about AIH)
including 844
cases and 1,522 controls were identified. The combined results based on
all studies showed that there was a statistically significant link
between
Apa1 and #autoimmune liver diseases (OR=0.85, 95%CI 0.74-0.96, P=0.058,
for a vs. A; OR=0.75, 95%CI 0.58-0.97, P=0.212, for aa vs. AA; OR=0.78,
95%CI 0.63-0.98 P=0.235, for Aa vs. AA; OR=0.77, 95%CI 0.63-0.94,
P=0.231, for Aa+aa vs. AA), while the Bsm1 and Taq1 don’t show the
association
with autoimmune liver diseases.
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