Journals on Biomedical Engineering - BJSTR Journal

Abstract

After surgical operation or #trauma, postoperative hyperglycae- mia develops as a result of increased glucose production combined with decreased glucose uptake in peripheral tissues [1-2]. This is largely as a result of #insulin resistance which is transiently induced within the stressed patient. It has been suggested that mechanisms for this phenomenon include the action of pro-inflammatory cytokines and the decreased responsiveness of insulin-regulated glucose transporter proteins [1-2]. It is also noticed that the degree of insulin resistance is proportional to the magnitude of the injurious process [1-2]. Following routine upper #abdominal surgery, insulin resistance may persist for approximately 2 weeks [1]. Clinically postoperative patients with insulin resistance behave in similar manner to individuals with type II diabetes mellitus and are at increased risk of #sepsis, deteriorating renal function, #polyneuropathy and death [1-2].The mainstay management of insulin resistance is intravenous insulin infusion. Insulin infusions may be used in either an intensive approach (i.e. sliding scales are manipulated to normalise the blood glucose level) or a conservative approach (i.e. insulin is administered when the #blood glucose level exceeds a defined limit and discontinued when the level falls [1].

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Post Operative Hyperglycemia-An Under Investigated Disease in West Africa by Jonathan L Ajah in BJSTR

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