Abstract
After surgical operation or #trauma, postoperative hyperglycae- mia
develops as a result of increased glucose production combined with
decreased glucose uptake in peripheral tissues [1-2]. This is largely as
a result of #insulin resistance which is transiently induced within the
stressed patient. It has been suggested that mechanisms for this
phenomenon include the action of pro-inflammatory cytokines and the
decreased responsiveness of insulin-regulated glucose transporter
proteins [1-2]. It is also noticed that the degree of insulin resistance
is proportional to the magnitude of the injurious process [1-2].
Following routine upper #abdominal surgery, insulin resistance may
persist for approximately 2 weeks [1]. Clinically postoperative patients
with insulin resistance behave in similar manner to individuals with
type II diabetes mellitus and are at increased risk of #sepsis,
deteriorating renal function, #polyneuropathy and death [1-2].The mainstay management of insulin resistance is intravenous insulin
infusion. Insulin infusions may be used in either an intensive approach
(i.e. sliding scales are manipulated to normalise the blood glucose
level) or a conservative approach (i.e. insulin is administered when the #blood glucose level exceeds a defined limit and discontinued when the
level falls [1].
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Post Operative Hyperglycemia-An Under Investigated Disease in West Africa by Jonathan L Ajah in BJSTR
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