Monday, October 29, 2018

Following the Clinical and Functional Status of an #Adolescent with #CysticFibrosis: Case Report by Cássio Daniel Araújo da Silva in BJSTR

Abstract

#CysticFibrosis (CF) is a multisystem #geneticdisease whose main cause of #morbidity and #mortality is progressive impairment of lung function associated with loss of quality of life and functional capacity. We report the clinical case of an 18-year-old adolescent accompanied at a reference center with #bronchialhyper-secretion, recurrent infections, bacterial colonization, important obstructive ventilatory disorder, and pulmonary #computedtomography (CT) showing a heterogeneous pattern. The authors emphasize the importance of continuous monitoring of #pulmonary, nutritional and functional parameters, allowing for more effective early interventions.




Benign #Paroxysmal Positional Vertigo: Differential #Diagnosis in Children by Sergio Carmona in BJSTR

Abstract

We present the case of a 14-year-old girl, who presented with a positional #vertigo of second duration, compatible with BPPV, but whose final #diagnosis was a #cavernoma in the #cerebellum. We emphasize the importance of keeping in mind the different etiologies of #vestibularsyndrome in children.




Metal Organic Framework #NanoParticles: Potential Contrast Agents for #MagneticResonance Imaging by Wenyan Dan in BJSTR

Abstract

Metal-organic framework #nano-particles are a type of novel organic-inorganic #hybridmaterials, which has been investigated as potential contrast agents in #magneticresonance imaging (MRI). This mini review focuses on recent research progress concerning the #synthesis, #stability and #cytotoxicity of #metalorganicframework nano-particles.




Saturday, October 27, 2018

#Technological Improvement and Public #Politics in Acute #Myocardial Infarct Treatment by Carvalho G in BJSTR

In the face of a #gigantic technological evolution in the study, #diagnosis and treatment of #cardiovascular diseases, they continue to be responsible for high rates of mortality and #morbidity throughout the world. In this context, acute myocardial infarction is a major #villain, abridging the active life of a growing population. Even with technological advancement in means for the adequate treatment of this #pathology, these means become obsolete without measures to promote orientation of the population in recognizing g their symptoms and seeking medical attention.




Automatic Generation of #Drug Concentration #Gradient by a #Modified #Ink-Jet Printer and its Application in #Drug Screening by Yong Luo in BJSTR







Manual preparation of drug concentration gradient is #labor-intensive and limits the efficiency of a drug screening to some extent, especially at large scale. In this study, we reported an automatic method to generate drug concentration gradient in 24-well plate. We loaded drug solution in a modified hot #ink-jet printer, designed printing pattern in the WORD software, customized the concentration gradient in the WORD software by #RGB coding, and finally printed the drug concentration gradient in the 24-well plate. A drug concentration gradient can be automatically generated within 5s in arbitrary pattern. On the basis of this flexible technology, we developed an ink-jet printer-based drug screening assay. Concentration gradient of #5-fluorouracil, as well as Mcf-7 cells, was printed in the 24-well plate, and the inhibition rate of #Mcf-7 cells was measured by MTT method. This was the first time that hot inkjet printing technology was used in drug screening.




#Protraction Effect of Rampa on #Maxillae, Upper Airway and #Hyoid Bone #Position; Finite Element Analysis by Bumkyoo Choi in BJSTR


This paper presents the effectiveness of #RAMPA (Right Angle Maxillary Protraction Appliance) system, i.e. RAMPA combined with ROA (RAMPA Oral Appliance), on human maxillae by analyzing the #deformations from #protraction forces with finite element method. In addition, the dimensional changes of the upper airway, skeletal facial and #hyoid position changes by using cone-beam computed #tomography in patients who were treated with RAMPA therapy were assessed clinically.




#Dysmenorrhea: A #Randomized Controlled Clinical Trial #Evaluating a #Novel Treatment Approach by Yossef Ezra in BJSTR



Study participants were women experiencing #dysmenorrhea monthly (for the 6 preceding months) at a level >5 on the visual analog scale (0-10), who were otherwise healthy. The study #participants also collected their #menstrual fluid for 2 baseline months, while recording their pain levels (primary outcome) systematically. A correlation between menstrual fluid characteristics and menstrual pain was studied, too.




The #Importance of Basic and #Applied Natural Sciences in Service of #Medicine by Hatil Hashim EL-Kamali in BJSTR

The enormous diversity of #microorganisms in the environment offers an almost unlimited gene pool for new enzymes and metabolic pathways. The discovery of new natural products continues to be of great interested for the production of #pharmaceuticals. An exciting approach to generating new products is to evolve novel metabolic pathways in a microbial cell by means of the technique of metabolic engineering. Cell culture is playing an increasingly more significant role in drug discovery. Animal cell biotechnology constitutes an important field in #Biotechnology nowadays. Animal cells produce many biological of great value involving enzymes, hormones, growth factors, viral vaccines, or #monoclonal antibodies, and many therapeutic proteins require #post-translational modifications which can be only fully performed by animal cells. Insect virus, immune-regulators or whole cells, which are used for toxicological testing, can be obtained from animal.




Friday, October 26, 2018

#Quality by Design and Process Analytical Technology: Important Tools for Buliding Quality in #PharmaceuticalProducts by Sunil Ashrani in BJSTR




Abstract

ICH Q8 guideline defines #Quality by Design as “a systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quality risk management. The QbD based approaches provides a high degree of assurance that #pharmaceuticalmanufacturingprocess is adjustable within a design space and hence the process is robust and managed with a control strategy developed using modern #statisticalprocess control methods. It enables a lifecycle approach to validation/continuous process verification. The building of Quality into the manufacturing products at its design stage is very important to reduce expenditure, time & energy. Also the market recall of products due to batch failure is reduced to minimum with the use of QbD. PAT is also related to QbD. It refers to Process #analyticaltechnology. PAT has been defined as “A system for #designing, #analyzing, and controlling manufacturing through measurements, during processing of critical quality and performance attributes of raw and in-process materials and processes, with the goal of ensuring final #productquality”. The present paper deals on these two terms QbD and PAT.


https://biomedres.us/abstracts/BJSTR.MS.ID.000704.php

https://biomedres.us/pdfs/BJSTR.MS.ID.000704.pdf

https://biomedres.us/fulltexts/BJSTR.MS.ID.000704.php

#Quality by Design and Process Analytical Technology: Important Tools for Buliding Quality in #PharmaceuticalProducts by Sunil Ashrani in BJSTR

#Preventing and Managing Burnout: What have we learned? by Shailesh Kumar in BJSTR

Abstract

Burnout is a #psychologicalresponse to exposure to chronic stressors at work and is characterised by high levels of #emotionalexhaustion, #depersonalisation and reduced personal accomplishment. Expression of burnout is said to be mediated by internal and external factors that act in predisposing, precipitating, perpetuating and protective roles. Active screening for burnout in employees using affective, cognitive, #behavioural and motivational signals helps raise awareness and ensure prompt intervention is offered. Systematic reviews have identified the significance of combining individual and organisational intervention strategies which appear to work best if intensive and booster sessions are offered in conjunction.




Comparison of Intercropped Sorghum- #Soybean Compared to its Sole #Cropping by Saberi AR in BJSTR

Abstract

In order to find the best planting pattern of soybean (#Glycine max L. Merill) with #sorghum (Sorghum bicolor L.) intercropping, this research performed in Gorgan and Aliabaad. Experiment compared on three levels inform of pure sorghum with density of 250000 plant per hectare, #intercropping of sorghum and soybean with density of 250000 and 400000 plant per hectare, respectively and intercropping of sorghum and soybean with density of 300000 and 480000 plant per hectare, respectively. The number of planting lines was 60 liens with length of 66.66 meters and 50cm interval. For measuring of plant height, number of tiller, stem diameter and number of node, 10 bushes randomly harvested by using quadrate. By the way total surface area based of project protocol also #harvested. For the results analysis t-test applied. Fresh forage production at treatment of intercropping with 300000 and 480000 plant density for sorghum and #soybean, respectively in Gorgan %33.33 and in Aliabad %34.32 had priority compared to check treatment (sole cropping of sorghum with density of 250000 plants per hectare). Mean comparison of dry forage also indicated %24.01 increasing in Gorgan and %26.12 in Aliabaad.




A New Insight to the #Pathogenesis of Lumbar Discal #Cyst: Two Case Reports by Xinyu Liu in BJSTR

Abstract

#Discalcysts are uncommon causes of low back #pain and radiculopathy. Due to the diversity of discal cysts was reported by about 50 case reports; we do not yet have a detailed understanding of their natural history, #etiology or pathogenesis. Here, we report two unique discal cysts to give a new insight to our understanding of the #pathogenesis of discal cysts.




Layer of Protection Analysis on #Sterilization Process Using #EthyleneOxide by Kyoshik Park in BJSTR

Abstract

Layer of protection analysis (LOPA) was conducted on #toxic and #flammable hazard of #sterilization process using #ethyleneoxide. Hazard associated with the process were studied using HAZOP and scenarios were developed by applying the HAZOP result. For each scenario, independent protection layers (IPLs) were identified and their frequencies were estimated. Three additional IPLs were considered such as personal protection equipment, monitoring device, and #ventilation window. By adding such IPLs, the risk was estimated to be reduced to less than chances per million.




Thursday, October 25, 2018

Clinical Study the Relationship between High-TSH Degree and Changes of LDL-C Level in #PregnantPatients’ #Serum by Xu Ke in BJSTR

Abstract

Objective: It was to investigate the relationship between high-TSH degree and changes of LDL-C level in pregnant patients’ #serum and take analysis of its influencing effects.
Methods: All subjects were collected from the Yancheng First People’s Hospital from January 2014 to December 2015, who was diagnosed by the #Endocrinology Department. Then it analyzed their #biochemicalindicators and blood liquid parameters in their serum. Additionally, we investigated their epidemiological data, including the disease history and #genes. At last it took regression analysis of its relevance.
Results: High-TSH degree and changes of LDL-C level are risk factors leading to #hypertension, #cardiovascularsymptoms, symptoms of digestive tract, pregnancy #ultrasound indicating small-sized fetus and they are related to one another (P<0.05); Whereas it has nothing to do with gestational diabetes mellitus, preterm birth history and #autoimmunediseases. In the whole, high-TSH degree group, the high cholesterol could cause premature birth, elevated blood sugar, high blood pressure prenatal, #postpartum infection and #preeclampsia (P<0.05)




The Use of Volatile #Inhibitors to Suppress Corrosion of #Metals in the Atmosphere of Livestock Buildings by L E Tsygankov in BJSTR

Abstract

At room temperature, the protective efficacy of the #volatileinhibitors (VIC) “IFHAN-A” (A-112, 114 and 118) was studied under #atmosphericcorrosion of carbon steel St3, brass L62 and copper M2 in the presence of #corrosionstimulants (CS) in the air: CO2 ((0.2-0.6) vol. %); H2S ((10- 30) mg /m3); NH3 ((20-60) mg /m3) and 100% relative #humidity, which simulates the atmosphere of livestock buildings. In the case of #carbonsteel in the presence of a binary mixture of CSs: CO2 + NH3, CO2 + H2S and NH3 + H2S, the protective action of the VIC is between 67 and 95%. When #corrosion of brass and #copper, the protective capacity of IFHAN-112 and IFHAN-118 decreases accordingly to 10 (Cu, IFHAN-112, NH3 + H2S) and 13 (brass, IFHAN-118, СО2 + H2S) % or 30% (brass, IFHAN-118, NH3 + H2S). These VIC stimulate copper corrosion in the presence of a binary mixture (CO2 + H2S). Only in the presence of IFHAN-114, the protective effect does not decrease below 74%.




The Use of Buffering Solutions in the #Pediatrics Local #Anesthesia to Reduce the Pain of Minor Procedures by Eduardo de Oliveira Duque-Estrada in BJSTR

Abstract

The #localanesthetics are widely u sed in minor #pediatricsurgicalprocedures. The major problem with their use is the resulted pain experienced by the patients at the time of #injection. To discuss those situations in the light of the medical literature we present this mini-review.




Is a detection of ‘Free-Floating’ #ChemicalProperties Possible? by Bernd Lindemann in BJSTR

Abstract

The claim that in #olfactionobjectless properties are detected treats abstract properties as if they were concrete objects, it is reification. Primary events of #olfactoryperception, leading to a population message indicating #odourquality, involve a detection of #molecularobjects owning properties, not of objectless properties.




Some #Nano Bio-Mofs Evaluated For Storage Purpose of #Drugs by Muhammad Athar in BJSTR

Abstract

#Nanobio-MOF compounds 3-5 (#copperserinate, copper prolinate and copper threoninate) have been evaluated for successful in vitro drugs adsorption of three drugs, named #terazosine, #telmisartan and #glimpiride. Pore sizes and BET surface areas were recorded on N2 adsorption isotherms. In order to elaborate the phenomenon of #invitro drugs adsorption in all these compounds we obtained TGA and PXRD spectra of them. The high performance liquid #chromatography (HPLC) was used to monitor the amounts of adsorbed #drugs and its slow release from all these compounds.




Sunday, October 21, 2018

Design Concept of #Tissue-Engineered Products for Use in Emergency and Critical Care #Medicine by Yoshimitsu Kuroyanagi in BJSTR

Abstract

Three types of #tissue-engineered products were developed using cell, growth factor, and #biomaterial. The first product is a CDS composed of allogeneic fibroblasts combined with a HA and Col spongy sheet. #Fibroblast can release various growth factors that are essential for wound healing. HA and Col have a potential to enhance #woundhealing. This CDS can be #cryopreserved for a long period of up to clinical use. The clinical study demonstated that #allogeneic CDS is a useful product. The second product is a wound dressing composed of HA and Col containing EGF. EGF has a #potential to enhace wound healing. This wound dressing is a freeze-dried spongy sheet, thereby the efficacy of EGF can be kept for a long period of up to clinical use. The clinical study showed that EGF-incorporating wound dressing is a practical product. The third product is an anti-adhesive #spongysheet composed of HA and Col containing EGF. This is also a #freeze-driedspongy sheet. The animal study indicated that EGF-incorporating anti-adhesive spongy sheet is a promissing product.



Factors to Consider in #Algal-Strain Selection for Commercial Manufacture of #Biofuels and Co-Products by Pierre Wensel in BJSTR

Abstract

Commercialization of algal-based processes for #biofuels and #co-products is constrained upstream during #cultivation by low productivity, contamination by invasive species, unsustainable and inefficient supply of nutrients (e.g. #nitrogen and #phosphorous), #inorganiccarbon, and water, exposure to environmental factors, and limited available land acreage for inoculum and primary cultures. It is also constrained downstream by costly and inefficient harvesting, product extraction, #thermochemicalconversion, #hydrotreatment, and upgrading. Overcoming these obstacles to commercialization requires not just piecemeal incremental improvements, but rather a comprehensive and fundamental re-consideration regarding the selected algae and its associated cultivation, #harvesting, biomass conversion, and refinement. Factors pertaining to algal-strain selection for commercial operations are presented below.



Liver Fatty Acids Profile of Rats Fed Ketogenic Diet

  Liver Fatty Acids Profile of Rats Fed Ketogenic Diet Introduction The ketogenic diet (KD) ‒ characterized by a low carbohydrate content an...