May the New year bring to you warmth of love a light to
guide your path towards a positive destination. Happy New Year 2019
New Year #Wishes from BJSTR
Monday, December 31, 2018
Friday, December 28, 2018
Statins Related Reduction In Major Ventricular Tachyarrhythmias (TV/FV) In Patients With Ischemic #Cardiopathy Undergoing ICD Implantation For Primary Prevention by Massimiliano Manfrin in BJSTR
Abstract
Purpose: to evaluate the #anti-arrhythmiceffect of #statins in patients receiving an implantable #cardioverter-defibrillator (ICD) for
ventricular #tachycardia/ventricular #fibrillation (VT/VF).
Methods: 85 patients with ischemic dilated cardiomyopathy
undergoing ICD implantation for sudden cardiac death (SCD) prevention
(primary prevention) were enrolled in the study. 63 patients (72%) were
on treatment with statins (group 1), and 22 were not (group 2). The
following end points were analyzed: recurrences of #ventriculararrhythmias (VA) requiring ICD intervention and mortality.
Results: after a median follow up of 46.2 months
(interquartile range 26.9 - 72.8 months) 28 patients (32.9%) had at
least one VA which
required ICD intervention. #Multivariateanalysis showed that treatment
with #statins was the only independent predictor of arrhythmic events
reduction (events requiring ICD intervention) (p=0.042). Under the 63
patients of group 1, 17 (27%) had appropriate ICD intervention, while
under the 22 patients of group 2, 11 (50%) had appropriate ICD
intervention (p=0.0185). The mortality in group 1 was 28.6% (18
patients),
while in group 2 was 50% (11 patients) (p=0.0284).
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Major Compounds from Ocimum Basilicum l. and their #AntimicrobialActivity against Methicillin-Resistant #StaphylococcusAureus by Thongchai Taechowisan in BJSTR
Abstract
Sweet Basil (#OcimumbasilicumLinn.) has a variety of #therapeuticproperties, including antimicrobial activity. This study aimed to
determine the antibacterial activity of the major chemical components in
the crude extract against #methicillin resistant #Staphylococcusaureus
(MRSA) isolated from the clinical specimens. TLC and column
chromatography resulted in the separation of two major compounds. On the
basis of the spectral data, they were identified as #linalool (1) and
1,8-cineole (2). #Antibacterialactivity of crude extract and isolated
compounds
was evalusted by disc diffusion, MIC and MBC against 9 multi-drug
resistance S. aureus isolated from clinical specimens. The crude extract
and
isolated compounds exhibited an excellent antimicrobial activity at a
dose level of 34.5 mg/disc for disc diffusion method. The crude extract
and linalool showed higher activity against tested MRSA with MIC
(<0.09 mg/ml) and MBC (≤ 0.09 to 0.38 mg/ml) than 1,8-cineole. The
results
suggest once again that the antimicrobial activity of the crude extract
and major isolated compounds, linalool and 1,8-cineole are a resultant
of the #antibacterialproperty against MRSA.
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https://biomedres.us/fulltexts/BJSTR.MS.ID.000910.php
Major Compounds from Ocimum Basilicum l. and their #AntimicrobialActivity against Methicillin-Resistant #StaphylococcusAureus by Thongchai Taechowisan in BJSTR
Thursday, December 27, 2018
Fast Method for Quantitative Determination of Methylene Blue by Micellar #ElectrokineticChromatography by Michał J Markuszewski in BJSTR
Abstract
The aim of the study was to develop and optimize a simple, fast and
applicable method for the quantitative determination of #methyleneblue. Different parameters, such as composition of #separationbuffer, #pHvalue and injection time were investigated in order to obtain the best
peak shape and reproducibility within the shortest analysis time. The
method developed demonstrated linear response over the range of 20-
100 μg/ml. #Micellarelectrokineticchromatographic assay proposed is
favorable in terms of the overall #analysis time and method simplicity.
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Fast Method for Quantitative Determination of Methylene Blue by Micellar #ElectrokineticChromatography by Michał J Markuszewski in BJSTR
Factors Affecting Transfer of Training to the Workplace after Faculty Development Program: what do Trainers Think? by Muhammad Zafar Iqbal in BJSTR
Abstract
Introduction: Faculty development plays pivotal role in
#medical education if the institutes aim to develop competent and
effective
teachers. The eventual goal of faculty development is to transfer the
newly acquired knowledge and skills to workplace to influence learning.
If
the training programs fail to foster transfer of training then the
effectiveness of these #trainingactivities decreases significantly.
Objective: The current study aims to explore the factors that are involved in hindering or aiding the transfer of #training (newly learned
competencies) to workplace i.e., educational milieu.
Methods: This is cross-sectional qualitative study that has
used purposive #samplingtechnique. Seven program developers contributed
in
the study. The data was collected through semi-structured interviews,
which was then analysed using #thematicanalysis. The interviews were
commenced between October 2017 to January 2018.
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Wednesday, December 26, 2018
#OxidativeDamage of Carotid Arteries in #DiabeticPatients by Ioannis Mamarelis in BJSTR
Abstract
In the present study, FT-IR spectra were used to study the carotid
arteries of 20 #diabeticpatients. From the comparison of infrared
spectra
between insulin-dependent (type II) diabetic patients or diabetics on
#oralhypoglycemicdrug treatment with the corresponding patient spectra
having normal blood glucose levels, it was found that
insulin-dependent(type II) diabetic patients showed more pronounced
changes throughout
the #absorption spectrum range (4000-800 cm-1). Particularly, the
observed increase of the intensities of the stretching vibration bands
of
ethylene (vCH2) groups indicated that the #lipophilicenvironment of the
membranes is significantly altered. This conclusion is attributed to the
increase in the destructive effect of free radicals produced during
oxidative stress in diabetics. Also from the shifts of the amide I and
amide II
absorption bands to lower frequencies it is concluded that the secondary
structure of proteins has been changed from α-helix to β-sheet and
random coil. The most significant changes were observed in the area
where the C-O-C groups of sugars and C-O-P-O sugar-phosphate groups of
DNA and #phospholipids absorb as a result of the disease.
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#OxidativeDamage of Carotid Arteries in #DiabeticPatients by Ioannis Mamarelis in BJSTR
#OxovanadiumComplexes in Bio Medical Applications by Jyothy Gopurathinkal Vijayan in BJSTR
Abstract
Coordination #chemistry of #Vanadium is largely dependent on the
oxidation reduction characteristics of metal center. Vanadium and its
oxoions
ie, vanadium (IV) and (V) are used as efficient #inhibitors of phosphate
#metabolizingenzymes and also perform as #activators. Vanadium
oxo-ions are very crucial agents as insulin enhancing agents and
anti-tumor agents. These oxo-ions exhibit redox properties under #physiologicalconditions. They are very efficient and act as a cofactor for enzymes in
blood sugar metabolism, lipid and cholesterol metabolism and hormone
production. Advancements in the medicinal applications of #oxovanadiumcomplexes have stimulated their design and #synthesis.
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#OxovanadiumComplexes in Bio Medical Applications by Jyothy Gopurathinkal Vijayan in BJSTR
Monday, December 24, 2018
Treatment of #FemoralNeckFractures with Dynamic Hip Screw in Young Adults by Mustufa Pervez in BJSTR
Abstract
#Dynamichipscrews have been a mainstay of treatment for
#intertrochantericfractures of the proximal femur and are also used to
treat
femoral neck fractures. Femoral neck fractures are usually common in
older age but can also present in younger individual usually due to high
energy trauma. Treatment of these fractures in young adults is debated
due to higher energy demands of the age and need to salvage the bone
instead of opting for a hemi arthroplasty or total #hiparthroplasty as
with older patients. Different other treatment options such as multiple
#cannulatedscrews have also been proposed but there still lies no
consensus for the ideal treatment of such fractures. Displaced fractures
are
commonly associated with a vascular necrosis of the femoral head and
multiple researches have been performed in this regard but if success
of union occurs after a Dynamic hip screw is performed, the patient is
able to regain his near physiological hip. Good bone quality and no
comorbids usually present as an advantage in younger patients but still
the surgery haunts orthopedic surgeons with its non-union and a
vascular necrosis rates. Good anatomical reduction and stable fixation
remains a mainstay of the treatment and can be perpetuated by a further
use of a de-rotation screw.
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Treatment of #FemoralNeckFractures with Dynamic Hip Screw in Young Adults by Mustufa Pervez in BJSTR
Agro-Industrial Residues Utilization for #SurfactinProduction: Cassava Wastewater by Cristiano José de Andrade in BJSTR
Abstract
#Biosurfactants are #amphiphiliccompounds produced,
essentially, by #microbialcells. The production/applications of
biosurfactants are aligned to the green chemistry concept, which
includes antimicrobial (bacteria, fungal, mycoplasma, etc), microbial
enhanced oil recovery (MEOR), and emulsification, among others
[1]. Surfactin, one of the most well-know biosurfactants, was first
found in 1968 by Arima, Kakinuma e Tamura [2]. Currently, there
are a few #surfactin manufacturers as Lipofabrik and Sigma Aldrich
that use mineral salt media for surfactin production. Regarding
surfactin production, the culture medium represents ≈ 30% total
production cost. Thus, some agro-industrial residues have been
investigated as alternative culture medium such as olive mill waste,
brewery wastewaters, sugarcane and beet molasses, whey, cassava
wastewater, etc [3]. In this sense, the cassava processing industry
generates ≈ 300 liters of cassava wastewater/ton of cassava, residue
which currently has not industrial application. Cassava wastewater
contains high minerals (potassium, calcium, magnesium, etc),
carbon and nitrogen concentrations, which allow a good microbial
growth: bacteria, fungi and yeasts.
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Agro-Industrial Residues Utilization for #SurfactinProduction: Cassava Wastewater by Cristiano José de Andrade in BJSTR
Thursday, December 20, 2018
#NeonatalSepsis Past to Present by Santosh Kumar Kamalakannan in BJSTR
Abstract
#Neonatalsepsis is a clinical syndrome characterized by systemic
signs of infection and #bacteremia in the neonatal period [1]. Neonatal
sepsis is a major cause of #mortality and #neurodevelopmentalimpairment among #neonates. It contributes to nearly 30 % of
neonatal deaths in developing countries [2]. Inherent factors like
poorly developed innate #immunesystem, immature skin barrier,
#mucosaldefense mechanisms and blood brain barrier contribute
to the increased susceptibility of the neonates to infection .Early
recognition and aggressive management plays a pivotal role in
saving these neonates. Bacterial infections are the most common
cause of septicemia in neonates but fungal and viral infections can
occur in the setting of an extreme premature baby and by vertical
#transmission from the mother.
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#NeonatalSepsis Past to Present by Santosh Kumar Kamalakannan in BJSTR
The Effect of long Distance #Transportation Stress on Cattle: A Review by Ashenafi D in BJSTR
Abstract
The aim of this article is to review scholarly work carried out on
the effect of long transportation stress. Stress due to long
transportation of
cattle can be measured by comparing baseline measurements when the
animal is not subjected to a stress inducing factors, to those measured
when an animal is experiencing a stressful event. Cattle transport
produces physical, psychological, and climatic factors that affect
animals with
different intensities and duration. The most pervasive factors of long
#transportation of cattle include, pre-transport management, the
attitudes
of stakeholders and inappropriate driving skills, laws and codes of
practice, methods used during handling, loading and unloading, the
design
of vehicle and equipment used for loading, and poor road conditions.
Other important factors causing stress are insufficient ventilation,
high
#stockingdensities, mixing of unfamiliar groups and social regrouping,
feed and water deprivation, noise, vibration, novelty, time of transit
and
length of the journey, #genetic differences between #breeds, and payment
of persons working with animals, actual physical #climaticcondition and
risk of disease #transmission.
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Simple, Rapid and Effective Separation of Nuclear #RedBloodCells from Peripheral Blood of Pregnant Women: Preliminary Study by Masato Kantake in BJSTR
Abstract
The analysis of #nuclearredbloodcells (NRBCs) in pregnant woman is
believed to be a practical, noninvasive prenatal test that is much
useful for understanding the prenatal fetal status. Here, we show a
simple, rapid and effective method to separate NRBC from maternal
peripheral blood with preterm labor. We used MACS Technology which is
based on MACS #MicroBeads, highly specific antibodies coupled
to super paramagnetic 50nm particles, MACS Columns containing a matrix
of #ferromagneticspheres, and MACS Separators providing a strong
magnetic field. This method could enrich the CD45-CD71+ cells from 0.3%
of whole blood cells to 93% of separated cells. When the fetal cell
ratio in these separated cells is high in some extent, our method may be
useful for further analysis. The yield of NRBCs from 2ml of maternal
blood by this method is enough to be used for not only targeted DNA
#methylavtion analysis but whole exome and whole #transcriptomeanalysis using next generation sequencer which may lead to progress in
#perinatology.
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Wednesday, December 19, 2018
Interpretation of #OrofacialPain Symptoms in the Basis of New Findings in Central and #PeripheralSensitizations by Yang Gu in BJSTR
Abstract
Aims: The paper provided an effective way of analyzing #orofacialpain cases based on new findings in central and peripheral
sensitization.
Methods: The non-systematic review was undertaken by searching English literature in the PubMed by pertinent keywords. Case reports
and publications with weak levels of evidence were excluded.
Results: Central and #peripheralsensitizations affect the pain perception mainly in the way of changing levels of neurotransmitters, the
sensitivity of neurotransmitter receptors, #neurogenicinflammation, and malnutrition.
Discussion: Understanding the mechanism deeply in the view of #neurophysiology and molecular biology will be helpful for clinicians to
interpret orofacial pain symptoms efficiently and find treatment plans appropriately. A comprehensive table was provided.
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#Pleurotusostreatus and Trametes versicolor, Fungal Strains as Remedy for Recalcitrant Pharmaceuticals Removal Current Knowledge and Future Perspectives by Marcelina Jureczko in BJSTR
Abstract
The consumption of #pharmacologicallyactive substances (PhACs) is
steadily increasing. According to their recalcitrant nature and
low biodegradability in wastewater treatment plants (WWTPs), they occur
in rivers, lakes, and even ground and drinking waters. Because
of that PhACs are considered to be emerging #pollutants. Therefore new
technologies which can be used to degrade them are investigated.
Two white-rot fungi (WRF) strains: #Pleurotusostreatus and #Trametesversicolor
show quite good PhACs removal values. Broad applications of
active and inactivated form of biomass are possible due to different
mechanisms of their action, such as #biodegradation by extracellular and
#intercellularenzymes or #biosorption. Thus, the versatility for applying
fungi, represent that this microorganisms are a promising tool to deal
with problem of #pharmaceuticalcompounds elimination from the
environment. In this work has been also presented future possibilities,
like
their application in waste water and sludge treatment or future
perspectives of removal of different group of pharmaceuticals by this
promising
and environmentally friendly technology
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Crossectional Study on the Prevalence And Economic Significance of #Hydatidosis in Slaughtered Ruminants at Debrezeit Elfora Export Abattoir Oromia Region Eastern Showa Zone, Ethiopia by Shimeles Abegaz in BJSTR
Abstract
An abattoir survey based study was conducted between November 2011
and March 2012 period, to determine the prevalence and
economic significance of #hydatidosis in slaughtered #ruminants. During
the study, Debrezeit Elfora export abattoir were visited twice a week to
examine the internal organs (livers, lungs, kidney and hearts) for the
presence of #hydatidcysts in ruminants and total 203 cattle, 384 sheep
and
547 goats were examined for the presence of hydatid cyst. It was found
that 42.86% of cattle, 7.03% of sheep and 4.39% of goats were infected
with this disease. The cysts in cattle, sheep and goats (P < 0.05)
were found mostly in lungs (41.4%, 7.03% and 4.39%) respectively,
whereas
the liver is second affected organ in all the three #species of animals
(p< 0.05%). In addition to this, six, two and one kidneys in cattle,
sheep
and goats respectively and one #heart in cattle only were infected with
hydatid cyst. In this study, the prevalence of hydatidosis and the
number
of cysts in ruminants were found different when the cattle, sheep and
goats examined were stratified based on their age and body condition.
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Tuesday, December 18, 2018
Insights of #PharmaceuticalCocrystals by Fpreshita P Desai in BJSTR
Abstract
Activepharmaceuticalingredients (API) and API drug products
developments are facing impending challenges as approximately
60-70% of newly discovered APIs belong to #biopharmaceutical classification system (BCS) Class II (poor solubility, good
#permeability) or BCS Class IV (poor solubility, poor permeability)
which results in low #oralbioavailability [1]. The conventional
approaches of formulating API salts and amorphous APIs are also
limiting because in most of these cases APIs either lack #ionizablefunctionalities or do not have strong ionization to allow salt
formation. Also, solubility enhanced amorphous form of APIs are
#thermodynamically unstable and are prone to transformation in
more stable but less soluble crystalline form upon storage. Further,
pH gradient across #gastrointestinaltrack adds an additional
challenge as some of these APIs possess variable pH dependent
solubility and some are unstable or are prone to degradation. In this
context, alternative approaches are being researched extensively.
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Insights of #PharmaceuticalCocrystals by Fpreshita P Desai in BJSTR
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